Ricerc@Sapienza

The research group led by Dr. Daniela Pontiggia investigates the plant cell wall as a dynamic platform for development, immunity, and environmental interaction. The team focuses on Cell Wall–Derived Damage-Associated Molecular Patterns (CW-DAMPs) — endogenous molecules released upon stress or infection that act as danger signals to modulate plant defense responses and growth.

Using biochemical, carbohydrate mass spectrometry, proteomic, and molecular biology approaches, the group studies the mechanisms underlying the perception and enzymatic oxidation of DAMPs such as oligogalacturonides (OGs) and cellodextrins, elucidating how their redox homeostasis contributes to the balance between plant development and immunity.

Recent work includes the valorization of agro-industrial by-products rich in bioactive oligosaccharides as sustainable tools for crop protection. The group aims to integrate fundamental research with applications in circular agriculture and plant biotechnology.

Driven by a creative and interdisciplinary approach, the group continues to explore the complex molecular networks linking cell wall dynamics, plant immunity, and agricultural sustainability, contributing to a renewed vision of applied plant biology.