Ricerc@Sapienza

The research group focuses its activity on an in-depth exploration of the cellular and molecular mechanisms governing the development, plasticity, aging, and pathophysiology of the nervous system. Particular attention is devoted to Duchenne Muscular Dystrophy, a condition traditionally considered muscular but now recognized for its significant implications on both the central and peripheral nervous systems, with consequences for neurodevelopment, cognitive functions, and multiple neurobiological processes. Within this framework, the group rigorously investigates the mechanisms underlying synapse formation, remodeling, and stabilization; cytoskeletal dynamics during axonal growth and regeneration; and the cellular and molecular pathways involved in neuroinflammation. The research strategy is strongly multidisciplinary, integrating morphological, biochemical, molecular, and functional approaches. In vivo and in vitro models are employed to precisely characterize how neural cells, circuits, and tissues change under physiological and pathological conditions.