Profact - Protein Factory Training Lab - is a research lab (BSL1) for medium throughput production of biomass for recombinant protein expression.
ProFact-Lab is hosted at the Department of Biochemical Sciences “A. Rossi Fanelli” (CU027), known for its long-lasting experience on recombinant protein production and characterization.
The α-1-antitrypsin (or alpha-1-antitrypsin, A1AT) Z variant is the primary cause of severe A1AT deficiency and forms polymeric chains that aggregate in the endoplasmic reticulum of hepatocytes. Around 2%-5% of Europeans are heterozygous for the Z and WT M allele, and there is evidence of increased risk of liver disease when compared with MM A1AT individuals. We have shown that Z and M A1AT can copolymerize in cell models, but there has been no direct observation of heteropolymer formation in vivo.
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