Recurrent PDL1 expression and PDL1 (CD274) copy number alterations in breast implant-associated anaplastic large-cell lymphomas
Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is a variant of anaplastic large-cell lymphoma arising within seroma effusion associated to breast implants. BI-ALCL is a rare disease, recently recognized as a new provisional entity by the 2017 revised WHO classification. All BI-ALCLs tested so far showed a "triple negative" genetic profile - negative for ALK, DUSP22, and TP63 rearrangements - and were characterized by mutational and gene expression profiles consistent with aberrant activation of the JAK/STAT pathway.