Ricerc@Sapienza

Background BehcEet's disease (BD) is a polygenic immune-mediated disorder characterized by a close association with the HLA-B∗51 allele. The HLA region has a strong linkage disequilibrium (LD) and carries several genetic variants (e.g. MIC-A, TNF-α genes) identified as associated to BD because of their LD with HLA-B∗51. In fact, the HLA-B∗51 is inherited as part of extended HLA haplotypes which are well preserved in patients with BD.

A key question in biology is to understand how interspecies morphological diversities originate. Plant roots present a huge interspecific phenotypical variability, mostly because roots largely contribute to adaptation to different kinds of soils. One example is the interspecific cortex layer number variability, spanning from one to several.

Rare hybridisations between deeply divergent animal species have been reported for decades in a wide range of taxa, but have often remained unexplained, mainly considered chance events and reported as anecdotal. Here, we combine field observations with long-term data concerning natural hybridisations, climate, land-use, and field-validated species distribution models for two deeply divergent and naturally sympatric toad species in Europe (Bufo bufo and Bufotes viridis species groups).

The conservation of semi-natural habitats represents a primary challenge for European nature conservation due to their great species diversity and their vulnerability to ongoing massive land-use changes. As these changes rapidly transform and phase out semi-natural habitats, conservation measures should be prompt and specifically focused on a sound assessment of the degree of conservation. Here we develop a methodological strategy for the assessment of the degree of conservation of semi-natural grasslands based on well-defined criteria rather than on expert opinion.

Many fossil specimens exhibit deformations caused by taphonomic processes. Due to these deformations, even important specimens have to be excluded from morphometric analyses, impoverishing an already poor paleontological record. Techniques to retrodeform and virtually restore damaged (i.e. deformed) specimens are available, but these methods genenerally imply the use of a sparse set of bilateral landmarks, ignoring the fact that the distribution and amount of control points directly affects the result of the retrodeformation.

Earthquakes cannot be predicted with precision, but algorithms exist for intermediate-term middle-range prediction of main shocks above a pre-assigned threshold, based on seismicity patterns. Few years ago, a first attempt was made in the framework of project SISMA, funded by Italian Space Agency, to jointly use seismological tools, like CN algorithm and scenario earthquakes, and geodetic methods and techniques, like GPS and SAR monitoring, to effectively constrain priority areas where to concentrate prevention and seismic risk mitigation.