Ricerc@Sapienza

The continuous crosstalk between microglia and neurons is required for microglia housekeeping functions and contributes to brain homeostasis. Through these exchanges, microglia take part in crucial brain functions, including development and plasticity. The alteration of neuron-microglia communication contributes to brain disease states with consequences, ranging from synaptic function to neuronal survival. This review focuses on the signaling pathways responsible for neuron-microglia crosstalk, highlighting their physiological roles and their alteration or specific involvement in disease.

Polymorphic variants of the gene encoding for metabotropic glutamate receptor 3 (mGlu3) are linked to schizophrenia. Because abnormalities of cortical GABAergic interneurons lie at the core of the pathophysiology of schizophrenia, we examined whether mGlu3 receptors influence the developmental trajectory of cortical GABAergic transmission in the postnatal life. mGlu3-/- mice showed robust changes in the expression of interneuron-related genes in the prefrontal cortex (PFC), including large reductions in the expression of parvalbumin (PV) and the GluN1 subunit of NMDA receptors.

The aim of this paper is to research legislation, taxes and subvention system of Italian and Croatian cooperatives as well as to compare economic efficiency through individual and aggregate importance of cooperatives. In this paper secondary data source were used, scientific and expert references, policy documents of relevant institutions, laws and strategies. Croatian and Italian cooperative system have different effect on the economy which is identified through basic indicators of cooperative development in both countries.

Morphogenetic events that occur during development and regeneration are energy demanding processes requiring profound rearrangements in cell architecture, which need to be coordinated in timely fashion with other cellular activities, such as proliferation, migration and differentiation. In the last 15 years, it has become evident that autophagy, an evolutionarily-conserved catabolic process that mediates the lysosomal turnover of organelles and macromolecules, is an essential " tool" to ensure remodelling events that occur at cellular and tissue levels.

Matrix metalloproteinases (MMPs) are a large family of ubiquitous extracellular endopeptidases, which play important roles in a variety of physiological and pathological conditions, from the embryonic stages throughout adult life. Their extraordinary physiological “success” is due to concomitant broad substrate specificities and strict regulation of their expression, activation and inhibition levels. In recent years, MMPs have gained increasing attention as significant effectors in various aspects of central nervous system (CNS) physiology.

Gender and sustainability are joined by twisting together in a logic and consequent way that only in the recent years has been commonly valorized. On the contrary, in the previous societies it seemed that the process of economic and social development was counterposed to the female identities and roles and today the cultural inheritance is the identification of the gender as a discriminating factor for female and the other gender identities as those of the most vulnerable actors, together with young and old people.

The project focuses attention on the rural areas with the aim of promoting sustainable economic development by the reuse of biomass waste, to multiplying and accelerating processes to improve the living conditions of the Kenyan population.

The long period of colonial subjection with its adverse effect on India’s economy made development one of the most urgent tasks. While the federal states were to a large extent enabled to devise and implement autonomous development policies, the centre also took up various initiatives aimed at optimising the use of resources in the localities. One of these initiatives, whose gradual evolution spanned over more than fifty years, is the establishment of village and district boards resulting in the so-called Panchayati Raj, i.e.