Ricerc@Sapienza

Objective: The use of dose-dense weekly chemotherapy in the management of advanced ovarian cancer (OC) remains controversial. The aim of this meta-analysis was to evaluate the efficacy of dose-dense regimen to improve clinical outcomes in OC patients with the inclusion of new trials.

Purpose: To evaluate the differences between the old and the new Gleason score classification systems in upgrading and downgrading rates. Materials and methods: Between 2012 and 2015, we identified 9703 patients treated with retropubic radical prostatectomy (RP) in four tertiary centers. Biopsy specimens as well as radical prostatectomy specimens were graded according to both 2005 Gleason and 2014 ISUP five-tier Gleason grading system (five-tier GG system). Upgrading and downgrading rates on radical prostatectomy were first recorded for both classifications and then compared.

At the beginning of 2020, coronavirus disease 2019 (COVID-19) spreads worldwide. Patients with ovarian cancer should be considered at high-risk of developing severe morbidity related to COVID-19. Most of them are diagnosed in advanced stages of disease, and they are fragile. Here, we evaluated the major impact of COVID-19 on patients with ovarian cancer, discussing the effect of the outbreak on medical and surgical treatment.

Purpose: Most of endourological procedures along the urinary tract have been widely practiced as outpatient operations, including surgery for BPH. This systematic review and meta-analysis was conducted to assess safety and feasibility of outpatient surgery for patients suffering from symptomatic BPH candidate for endoscopic disobstruction.

Spontaneous haemoperitoneum due to rupture of a vein overlying a myoma, however, is a rare entity it and may cause anaemia and hypovolemic shock. The first case was reported by Von Rokitansky in 1861 as an autopsy finding. To-date, less than 100 cases have been reported in the literature. We report a case of spontaneous rupture of a vein overlying leiomyoma causing life-threatening blood loss necessitating massive transfusion and emergency surgery.

Objective: The aim of this study was to assess the correlation between BRCA mutation status and disease presentation, treatment strategy, and survival in a multicenter series of recurrent high-grade serous ovarian cancer (HGSOC) women. Methods: A consecutive series of recurrent HGSOC patients with partially or fully platinum-sensitive disease admitted to the Gynecologic Oncology Units of the Catholic University of the Sacred Heart and Sapienza University of Rome.

Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including Alzheimer's disease (AD), Lewy body dementia (LBD), Parkinson's disease (PD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are associated with changes in brain networks. However, the underlying neurophysiological pathways driving pathological processes are poorly defined.

Introduction: Videothoracoscopy (VATS) is the gold standard for pneumothorax (PNX). However, in the last years, the surgical technique has been progressively modified towards less invasiveness to reduce postoperative pain and hospitalization. We present our experience with uniportal VATS to treat PNX.

The topic of the paper by Hino et al. (1) is crucial and it will become even more important in the future due to the increasing number of elderly patients in our surgical wards. The aim of authors was to retrospectively identify the risk factors for postoperative complications comparing two prognostic scores (Charlson Comorbidity Index and Glasgow Prognostic Score) and to assess long-term survival in a large multi-institutional cohort of patients aged 80 years or older.