voltage-clamp recordings | Ricerc@Sapienza

Patch clamp recording and fluorescence monitoring system for brain cells and slices- MicroSynRec

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the integrated electrophysiology/fluorescence system allows the concomitant monitoring of membrane currents and fluorescence in brain cellsform acute brain slices.

The laboratory is optimized for patch clamp recording of evoked and spontaneous synaptic activity. moreover, it allows the rapid application of exogenous subtances. fluorescence monitoring allows the analysis of cells and cell processes movement in slices

A novel action of lacosamide on GABAAcurrents sets the ground for a synergic interaction with levetiracetam in treatment of epilepsy

Epilepsy is one of the most common chronic neurological diseases, and its pharmacological treatment holds great importance for both physicians and national authorities, especially considering the high proportion of drug-resistant patients (about 30%). Lacosamide (LCM) is an effective and well-tolerated new-generation antiepileptic drug (AED), currently licensed as add-on therapy for partial-onset seizures. However, LCM mechanism of action is still a matter of debate, although its effect on the voltage sensitive sodium channels is by far the most recognized.