Brain MRI fiber-tracking reveals white matter alterations in hypertensive patients without damage at conventional neuroimaging
01 Pubblicazione su rivista
Carnevale Lorenzo, D', Angelosante Valentina, Landolfi Alessandro, Grillea Giovanni, Selvetella Giulio, Storto Marianna, Lembo Giuseppe, Carnevale Daniela
DOI: 10.1093/cvr/cvy104
ISSN: 0008-6363
Hypertension is one of the main risk factor for dementia. The subtle damage provoked by chronic high blood pressure in the brain is usually evidenced by conventional magnetic resonance imaging (MRI), in terms of white matter (WM) hyperintensities or cerebral atrophy. However, it is clear that by the time brain damage is visible, it may be too late hampering neurodegeneration. Aim of this study was to characterize a signature of early brain damage induced by hypertension, before the neurodegenerative injury manifests.