The World Health Organization (WHO) on March 11, 2020, has declared the novel coronavirus disease (COVID- 19) a global pandemic. Being closely related to severe acute respiratory syndrome coronavirus (SARS-CoV), the new virus has been named SARS-CoV-2 by the International Committee on Taxonomy of Virus. The aim of this project is the development of a nanoparticle-protein corona DNA vaccine technology for efficient protection against SARS-CoV-2 variants of concern that can be adapted quickly to new SARS-CoV-2 mutants. In vivo validation will allow us to select for the most powerful delivery platform that protects against SARS-CoV-2 infection in animal models and take this to phase I clinical testing.