Ricerc@Sapienza

KCTD containing Cullin3 adaptor, suppressor of Hedgehog (KCASH2) belongs to the KCASH family
of proteins, which are involved in the negative regulation of the Sonic Hedgehog (Hh) signaling pathway.
All members of KCASH family have shown to be downregulated in Hh dependent Medulloblastoma
(Mb), by either allelic loss or promoter methylation. Particularly, KCASH2 expression is reduced also
in other tumors, not directly connected with Hh pathway modulation; moreover, chromosome 11q,
where KCASH2 is localized, is lost in several sporadic tumors. In turn, correlation studies and data
of laboratory show a role of KCASH2 in differentiation and cell cycle regulation, suggesting its fine
regulation during development.