Ricerc@Sapienza

The aim of the study is to observe retrospectively the correlation between Oral
Squamous Cell Carcinoma (OSCC) and risk factors; including tobacco, alcohol and Family History
of Cancer (FHC). A total of 478 patients were included retrospectively from the database of the
Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome. A Test
Group (TG) consisted of 239 patients with a confirmed diagnosis of OSCC. A Control Group (CG)
consisted of 239 patients without history and/or diagnosis of oral cancer. The logistic regression
models were used to calculate the adjusted Odd Ratios (ORs) associated with alcohol, tobacco and
FHC; including the General Family History of Cancer (GFHC) and Family History of Head and
Neck Cancer (FHHNC) and their 95% Confidence Intervals (CI). The high rate of tobacco
consumption was associated with an OR of 1.035 (95% CI 1.001–1.070) and a statistical significance
(p = 0.041). Drinker patients showed a significant risk of developing OSCC (p = 0.05) and the OR
was 1.035 (95% CI 1.010–1.061). The GFHC was associated with a marginal risk of OSCC with an
OR of 1.095 (95% CI 0.953–1.259), without significance (p = 0.199). The FHHNC showed a notable
risk increase with an OR of 1.871 (95% CI 0.902–3.882), without significance (p = 0.092). Alcohol
and tobacco may be associated with an increase in the risk of OSCC.