Giuseppe Giannini | Ricerc@Sapienza

Publications

Title	Published on	Year
True conversions from RAS mutant to RAS wild-type in circulating tumor DNA from metastatic colorectal cancer patients as assessed by methylation and mutational signature	CANCER LETTERS	2021
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors	ONCOGENE	2021
A multidisciplinary approach for the differential diagnosis between multiple primary lung adenocarcinomas and intrapulmonary metastases	PATHOLOGY RESEARCH AND PRACTICE	2021
Comparison of two blood-based genotyping tests to investigate the KRAS G12C mutation in patients with non-small-cell lung cancer at failure of first-line treatments	DIAGNOSTICS	2021
Transcriptome of male breast cancer matched with germline profiling reveals novel molecular subtypes with possible clinical relevance	CANCERS	2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module	CELL REPORTS	2020
Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer	FRONTIERS IN ONCOLOGY	2020
PIK3CA somatic mutation in sinonasal teratocarcinosarcoma.	AURIS, NASUS, LARYNX	2020
Matched germline and tumor profiling in male breast cancer for the discovery of molecular subtypes with clinical relevance	Cancer ResearchCANCER RESEARCH	2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation	CELL DEATH & DISEASE	2020
A novel BRCA2 splice variant identified in a young woman	MOLECULAR GENETICS & GENOMIC MEDICINE	2020
A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer	CANCERS	2019
Transient disappearance of RAS mutant clones in plasma: A counterintuitive clinical use of EGFR inhibitors in RAS mutant metastatic colorectal cancer	CANCERS	2019
Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer	PEERJ	2019
Insight into genetic susceptibility to male breast cancer by multigene panel testing: results from a multicenter study in Italy	INTERNATIONAL JOURNAL OF CANCER	2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP	NATURE COMMUNICATIONS	2019
Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains CRC progression and chemoresistance	CANCER RESEARCH	2019
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk	ENDOCRINE CONNECTIONS	2019
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2	ONCOGENESIS	2019
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors	SCIENTIFIC REPORTS	2019

Progetti di Ricerca

Dissecting the role of the Nijmegen breakage syndrome protein in SHH-dependent tumorigenesis
Repressing or enhancing replication stress: the two sides of the coin to understand and tackle MYCN-dependent tumors.