Aim: We aimed to study the relation between hematic levels of polyfluoroalkyl substances (PFASs) and flame retardants and recurrent spontaneous abortion through investigating the serum levels of PFOS and TPhP in patients with recurrent abortion compared to fertile patients. Material and Methods: Forty normal blood sampling will be obtained from 20 women with regular menstrual cycle and a previous history of pregnancy and from 20 women always with regular menstrual cycle and a history of recurrent miscarriage. Objective: Based on these considerations, the objective of the present analysis was to identify the relation between hematic levels of PFASs and flame retardants and recurrent spontaneous abortion. The purpose of our study is going to detect the differential serum levels of PFOS and TPhP of recurrent spontaneous abortion patients.
Increasing evidence indicates that exposure to environmental contaminants negatively affects animal and human health. They have been defined by WHO as "an exogenous substance or mixture that alters function[s] of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or [sub] populations". Materno-fetal transmission of EDC with a negative impact on fetal outcome has also been demonstrated. EDC are a heterogeneous group of substances of different use, chemical structure and mechanism of action. Studies on animal models suggest that exposure to EDC may play a role in the pathogenesis of infertility(12). Previous data had also investigated the association between exposure to EDC and human infertility: they have shown that prolonged exposures to EDC can cause different reproductive disorders, including precocious puberty, oocyte aneuploidy, as well as an alteration in reproductive efficiency. In the broad panorama of EDCs present and investigated, two elements of particular current interest are poly-fluoroalkyl substances (PFASs) and flame retardants. Considering the importance that in the last few years has obtained the study of these factors both in human health as well as in male and female fertility, we wanted to analyze them in another pathological context, considering the already known impact of miscarriage on social life. The recurrent spontaneous abortion often remains a problem of difficult resolution. The objective of our study is to find altered expression serum levels of PFOS and TPhP in infertile patients and patients with recurrent miscarriage assuming a possible predictor of defective endometrial receptivity.