Von Willebrand factor with increased binding capacity is associated with reduced platelet aggregation but enhanced agglutination in COVID-19 patients: another COVID-19 paradox?
Patients with Coronavirus-associated disease-2019 (COVID-19) display alterations of the hemostatic system and the presence
of a prothrombotic status frequently leading to vascular complications. However, the impact of COVID-19 on platelet
activity, aggregation and agglutination still needs to be clarified. We measured total levels of von Willebrand factor (vWF)
and vWF binding to the platelet glycoprotein (Gp) complex (GPIb-IX-V), in a cohort of COVID-19 patients admitted to the