Ricerc@Sapienza

To evaluate whether grafting of autologous mesenchymal cells, adipose-derived stem cells, and platelet-rich plasma into the supracoroideal space by surgical treatment with the Limoli retinal restoration technique (LRRT) can exert a beneficial eect in retinitis pigmentosa (RP) patients. Twenty-one eyes underwent surgery and were divided based on retinal foveal thickness (FT) 190 or > 190 m into group A-FT and group B-FT, respectively. The specific LRRT triad was grafted in a deep scleral pocket above the choroid of each eye.

Purpose: To investigate the prevalence and progression of vitreo-macular interface disorders (VMID) phenotypes and their natural history in retinitis pigmentosa (RP). Methods: A total of 257 eyes of 145 RP patients with VMID were retrospectively evaluated. Patients were divided according to the VMID subtypes into epiretinal membranes (ERMs), vitreo-macular traction (VMT) group, and macular hole (MH). Serial eye-tracked spectral-domain optical coherence tomography (SD-OCT) and best-corrected visual acuity (BCVA) changes were analyzed for a mean follow-up of 36.95 months.

Both tissue repair and regeneration are a priority in regenerative medicine. Retinitis
pigmentosa (RP), a complex retinal disease characterized by the progressive loss of impaired
photoreceptors, is currently lacking effective therapies: this represents one of the greatest challenges in
the field of ophthalmological research. Although this inherited retinal dystrophy is still an incurable
genetic disease, the oxidative damage is an important pathogenetic element that may represent a