Ricerc@Sapienza

The G-Schemeis a well established framework for multi-scale adaptive modelreduction, whose effectiveness was demonstrated with reference to a number of test models,together with an identification of the critical areas that were in need of further theoreticaland computational refinement. In this communication, we report on how we enhanced thesolver performance.

Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the laws that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of experiments, including how to uncover evidence of biochemical features that may otherwise escape notice.