Ricerc@Sapienza

Background: Hydrogen sulphide (H2S) is enzymatically generated in various tissues and exerts many physiological effects that suggest its potential role as a regulatory mediator. H2S is involved in the regulation of vascular tone, erectile function, myocardial contractility, inflammation, neurotransmission and insulin secretion. In particular, this gaseous mediator influences the activation of cellular inflammatory processes.

Background: Osteoarthritis (OA) is the most common musculoskeletal disease in the world. OA is the result of an inflammatory and degenerative process affecting the entire joint. Osteoarthritis, especially involving the knee, has a relevant socio-economic impact in terms of drugs, hospital admissions, work absences and temporary or permanent invalidity. Therapy of knee osteoarthritis is based on pharmacological and non-pharmacological measures.