allosteric regulation

PLP-GROUP

PLP-GROUP

Our research group is interested in the regulation of VitaminB6 metabolism in bacteria and humans, and in diseases caused by Vitamin B6 malfunctioning.

Specifically, our studies focus on:

i) Transcriptional regulation of Vitamin $\text{B}_6$ metabolism in bacteria;

ii) Allosteric properties of proteins involved in Vitamin $\text{B}_6$ metabolism in bacteria and humans;

iii) Molecular basis of neurological diseases caused by defects in Vitamin $\text{B}_6$ metabolism;

Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from escherichia coli

In Escherichia coli, the synthesis of pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, takes place through the so-called deoxyxylulose 5-phosphate-dependent pathway, whose last step is pyridoxine 5'-phosphate (PNP) oxidation to PLP, catalyzed by the FMN-dependent enzyme PNP oxidase (PNPOx).

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