Multiple Herpes simplex virus-1 (HSV-1) reactivations induce protein oxidative damage in mouse brain. Novel mechanisms for Alzheimer’s disease progression
Compelling evidence supports the role of oxidative stress in Alzheimer’s disease (AD) pathophysiology. Interestingly, Herpes simplex virus-1 (HSV-1), a neurotropic virus that establishes a lifelong latent infection in the trigeminal ganglion followed by periodic reactivations, has been reportedly linked both to AD and to oxidative stress conditions.