Nodular thyroid disease with aging
Epithelial thyroid cancers (TC) comprise two differentiated histotypes (DTC), the papillary (PTC) and the follicular (FTC) TC which, following dedifferentiation, progress toward the poorly differentiated TC (PDTC) and the highly aggressive anaplastic TC (ATC). Even though thyroid cancer mortality did not change, its annual incidence has increased over the last two decades, largely due to the improved ability to diagnose malignant transformation in small non-palpable thyroid nodules.