A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer. Our experience in thyroid surgery
Abstract
Background: Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in
the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid
cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxidative stress in thyroid cancer
by analyzing the expression of two selenium antioxidant molecules, glutathione peroxidase (GPx1) and thioredoxin
reductase (TrxR1) in thyroid cancer cells.