The prevalence of valvular heart disease (VHD) rises with age, reaching 11.7% in individuals older than 75 years.1 In young individuals, VHD is usually related to the presence of a congenital valve abnormality, as bicuspid aortic valve (BAV) or mitral valve prolapse. This is also the case for athletes, where in the presence of these abnormalities few restrictions exist in eligibility
A mainstream in lipid management is to counteract the dose response association of elevated low-density lipoprotein cholesterol
We welcome the paper by Bhuva et al. (1) who investigated whether real-world exercise training for a first-time marathon can reverse age-related aortic stiffening, concluding that training even at relatively low exercise intensity reduces central blood pressure and aortic stiffness, equivalent to a 4-year reduction in vascular age. Nonetheless, although we found these data particularly interesting and novel, the report raises additional issues that should be addressed by the authors. First, only marathon finishers were included in the study.
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