Vascular wall–mesenchymal stem cells differentiation on 3D biodegradable highly porous CaSi-DCPD doped poly (α-hydroxy) acids scaffolds for bone regeneration
Vascularization is a crucial factor when approaching any engineered tissue. Vascular
wall–mesenchymal stem cells are an excellent in vitro model to study vascular remodeling due to
their strong angiogenic attitude. This study aimed to demonstrate the angiogenic potential of
experimental highly porous scaffolds based on polylactic acid (PLA) or poly‐e‐caprolactone (PCL)
doped with calcium silicates (CaSi) and dicalcium phosphate dihydrate (DCPD), namely PLA‐
10CaSi‐10DCPD and PCL‐10CaSi‐10DCPD, designed for the regeneration of bone defects. Vascular