Ricerc@Sapienza

The aim of this Italian multicenter study was to evaluate the diagnostic performance of a minimally invasive method for the detection of oral squamous cell carcinoma (OSCC) based on 13-gene DNA methylation analysis in oral brushing samples.

1. Introduction
In a recent study our research group described a non-invasive sampling procedure based on
DNA methylation analysis of a set of 13 genes with a high level of accuracy (sensitivity 96.6%,
specificity 100%) in the detection of squamous cell carcinoma of the oral cavity (OSCC) [1].
The purpose of the present study was to test the diagnostic performance of this non invasive
sampling procedure in an italian multicentric study.
2. Materials and Methods