MiRNAs as Potential Prognostic Biomarkers for Metastasis in Thin and Thick Primary Cutaneous Melanomas.
Background/Aim: The identification of novel
prognostic biomarkers for melanoma metastasis is essential
to improve patient outcomes. To this aim, we characterized
miRNA expression profiles in relation to metastasis in
melanoma and correlated miRNAs expression with clinicalpathological factors. Materials and Methods: MiR-145-5p,
miR-150-5p, miR-182-5p, miR-203-3p, miR-205-5p and miR211-5p expression levels were analyzed in primary cutaneous
melanomas, including thin and thick melanomas, and in
melanoma metastases by quantitative Real-Time PCR.