The AIEOP 2nd series of children and adolescents intracranial ependymoma. An integrated molecular and clinical characterization with a long-term follow-up
BACKGROUND: A prospective 2002-2014 study stratified 160 patients by resection extent and histological grade, reporting results in 2016. We reanalyzed the series after a median 119 months, adding retrospectively patients’ molecular features.
METHODS: Follow-up of all patients was updated. DNA copy-number analysis and gene-fusion detection could be completed for 94/160 patients, methylation classification for 68.