SARS- CoV-2

VIROLOGIA e MICROBIOLOGIA

VIROLOGIA e MICROBIOLOGIA

The Molecular Virology Laboratory is engaged in several lines of research mainly focused on persistent viral infections and their interaction with the host. In addition, following the emergence of SARS-CoV-2, the laboratory has initiated studies aimed at identifying elements useful for a deeper understanding of the relationship between this virus and the human host.

A major area of research concerns:

Infezioni virali mucosali

Infezioni virali mucosali

Caratterizzazione molecolare ed epidemiologica dei virus respiratori; il contributo della risposta immune dell’ospite alla patogenesi e alle sequele respiratorie.

Monocyte absolute count as a preliminary tool to distinguish between SARS-CoV-2 and influenza A/B infections in patients requiring hospitalization

Since the most frequent symptoms of novel coronavi- rus 2019 disease (COVID-19) are common in influenza A/B (FLU), predictive models to distinguish between COVID-19 and FLU using standardized non-specif- ic laboratory indicators are needed. The aim of our study was to evaluate whether a recently dynamic nomogram, established in the Chinese population and based on age, lymphocyte percentage and monocyte absolute count, might apply to a different context. We collected data from 299 patients (243 with COVID-19 and 56 with FLU) at Policlinico Umberto I, Sapienza University of Rome.

Role of computed tomography in predicting critical disease in patients with covid-19 pneumonia: a retrospective study using a semiautomatic quantitative method

Background: So far, only a few studies evaluated the correlation between CT features and clinical outcome in patients with COVID-19 pneumonia. Purpose: To evaluate CT ability in differentiating critically ill patients requiring invasive ventilation from patients with less severe disease. Methods: We retrospectively collected data from patients admitted to our institution for COVID-19 pneumonia between March 5th-24th. Patients were considered critically ill or non-critically ill, depending on the need for mechanical ventilation.

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