Bioconjugates

SYNLAB

SYNLAB

The early work of Botta group was devoted to the structural elucidation and synthesis of biological active molecules derived from plant in vivo. Since 1984, his group have been working in the field of in vitro plant tissue cultures. The general aim of the investigation was directed toward the understanding of biosynthetic pathways of the isolated metabolites and the isolation of the responsible enzymes. During this research, new plant enzymes (e.g. peroxidases) have been isolated, purified, and characterized by chemical and kinetic studies.

Direct conjugation of resveratrol on hydrophilic gold nanoparticles: Structural and cytotoxic studies for biomedical applications

Strongly hydrophilic gold nanoparticles (AuNPs), functionalized with citrate and L-cysteine, were synthetized and used as Resveratrol (RSV) vehicle to improve its bioavailability. Two different conjugation procedures were investigated: the first by adding RSV during AuNPs synthesis (1) and the second by adding RSV after AuNPs synthesis (2). The two different conjugated systems, namely AuNPs@RSV1 and AuNPs@RSV2 respectively, showed good loading efficiency (η%): η1 = 80 ± 5% for AuNPs@RSV1 and η2 = 20 ± 3% for AuNPs@RSV2.

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