Ricerc@Sapienza

The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating evidence in recent years has indicated that metabolic reprogramming is closely interrelated with the regulation of redox homeostasis, suggesting that the disruption of NRF2 signaling might represent a valid therapeutic strategy against a variety of solid and hematologic cancers.

The NRF2/KEAP1 pathway is a crucial and highly conserved defensive system required to maintain or restore the intracellular homeostasis in response to oxidative, electrophilic and other types of stress conditions. The tight control of NRF2 function is maintained by a complex network of biological interactions between positive and negative regulators that ultimately ensure context specific activation, culminating in the NRF2-driven transcription of cytoprotective genes.