Non-invasive prediction of genotype positive–phenotype negative in hypertrophic cardiomyopathy by 3D modern shape analysis
We propose a non-invasive procedure for predicting genotype positive for hypertrophic cardio- myopathy (HCM) in subjects that do not exhibit a left-ventricular wall hypertrophy condition (G+LVH−); the procedure is based on the enhanced analysis of medical imaging from 3D speckle tracking echocardiography (3D-STE). 3D-STE, due to its low quality images, has not been used so far to detect effectively the G+LVH− condition. Here, we post-processed echocardiographic images exploiting the tools of modern shape analysis, and we studied the motion of the left ventricle (LV) during an entire cycle.