Circadian rhythm sleep-wake disorders

Sleep-immune interactions and mental disorders

Prospective epidemiological studies suggest that sleep disturbance (ie, difficulties in sleep onset and sleep maintenance) is a robust predictor of major depression episodes and depression recurrence. In parallel, experimental endotoxin model support a role of innate immune activation (inflammation) in the aetiology of depression, yet the precise role played by sleep disturbance is poorly understood. Sleep disturbance may increase peripheral pro-inflammatory cytokines by upregulating NF-kB pathways, modulating gut-microbiota, autonomic and neuroendocrine (eg, HPA) activity.

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Human High Resolution EEG recording system with EOG, ECG, and EMG control channels / Platform of advanced EEG-EOG-ECG-EMG data analysis

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Electrically-shielded and sound-proof chamber for the recording of multi-electrode high resolution EEG activity and control EOG, ECG, and EMG activity in humans in conditions of quiet vigilance or sensory, cognitive, and motor tasks. Platform for an advanced quantitative data analysis.

Migraine and sleep disorders: a systematic review

Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs. The existence of a relationship between migraine and sleep disorders has been recognized from centuries by clinicians and epidemiological studies. Nevertheless, the exact nature of this association, the underlying mechanisms and interactions are complex and not completely understood.