Functional inactivation of drosophila GCK orthologs causes genomic instability and oxidative stress in a fly model of MODY-2
Maturity-onset diabetes of the young (MODY) type 2 is caused by heterozygous inactivating
mutations in the gene encoding glucokinase (GCK), a pivotal enzyme for glucose homeostasis. In
the pancreas GCK regulates insulin secretion, while in the liver it promotes glucose utilization
and storage. We showed that silencing the Drosophila GCK orthologs Hex-A and Hex-C results in
a MODY-2-like hyperglycemia. Targeted knock-down revealed that Hex-A is expressed in insulin