Ricerc@Sapienza

Langerhans Cell Histiocytosis is a rare hematologic disorder usually affecting children and most commonly involving the head and neck region. Primary oro-facial manifestations are rare, and their diagnosis is often challenging as they are numerous and often resemble common pathologies, refractory to conventional medical and/or instrumental treatments. For such reasons, the diagnosis is frequently delayed, as is the following staging and therapy onset.

Sleep disordered breathing in children designates a wide spectrum of respiratory disorders characterized by partial or complete obstruction of the upper airways. It ranges from primary snoring, its mildest clinical manifestation, to obstructive sleep apnea syndrome (OSAS): complete obstruction of the upper airways with cessation of airflow.

The establishment and subsequent worsening of a malocclusion is the result of a combination of factors dominated by the interaction between inheritance and environment and follows a dynamic process of temporal evolution. This transversal study, based on a sample of 579 children from the Caserta area in Southern Italy, investigates the potential worsening of malocclusions with age by measuring the relationship between the severity level of orthodontic abnormalities, evaluated through the IONT-DHC classification, and the age of the subjects.

Urinary mercury (Hg) levels are suitable to assess long-term exposure to both elemental and inorganic Hg. In this study, the urinary Hg levels of 250 children (aged 6–11 years) from three areas with different anthropogenic impacts in the Rieti province, central Italy, were assessed.