Physico-chemical properties influence the functions and efficacy of commercial bovine lactoferrins
Human and bovine lactoferrin (hLf and
bLf) are multifunctional iron-binding glycoprotein
constitutively synthesized and secreted by glandular
epithelial cells and by neutrophils following induction.
HLf and bLf possess very high similarity of sequence.
Therefore, most of the in vitro and in vivo studies are
carried out with commercial bLf (cbLf), available in
large quantities and recognized by Food and Drug
Administration (FDA, USA) as a safe substance.
Physico-chemical heterogeneity of different cbLf