antiretroviral therapy hiv

VIROLOGIA e MICROBIOLOGIA

The Molecular Virology Laboratory is engaged in several lines of research mainly focused on persistent viral infections and their interaction with the host. In addition, following the emergence of SARS-CoV-2, the laboratory has initiated studies aimed at identifying elements useful for a deeper understanding of the relationship between this virus and the human host.

A major area of research concerns:

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Efficacy and safety of dolutegravir-based regimens in advanced HIV-infected naïve patients: results from a multicenter cohort study

The aims were to describe efficacy and tolerability of regimens containing dolutegravir (DTG) in advanced ARTnaïve
people living with HIV (PLHIV) from the clinical practice.
The frequency of Immune Reconstitution Inflammatory Syndrome (IRIS), the estimated time of discontinuation
of the first ART regimen and the time to reach virological suppression in a multicenter cohort of
AIDS-presenters or late-presenters with CD4<350/μL were assessed.
We included 272 PLHIV: 120 (44%) AIDS-presenters and 152 (56%) late-presenters. The most frequent AIDSdefining