antibiotic resistance genes.

Virologia e Microbiologia

Our group has internationally recognized expertise in microbial genetics, bacterial genomics, computer science, and clinical microbiology as applied to the study of antibiotic resistance. At Sapienza, we have developed advanced expertise and instrumentation for bacterial genomics, and we have established methods to investigate the most relevant bacterial threats in nosocomial settings. In recent years, we have combined genomic approaches with innovative molecular methodologies to identify antimicrobial resistance mechanisms and to perform rapid molecular typing of resistant strains.

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Effect of urban wastewater discharge on the abundance of antibiotic resistance genes and antibiotic-resistant Escherichia coli in two Italian rivers

Background: Wastewater treatment plants (WWTPs) are microbial factories aimed to reduce the amount of nutrients and pathogenic microorganisms in the treated wastewater before its discharge into the environment. We studied the impact of urban WWTP effluents on the abundance of antibiotic resistance genes (ARGs) and antibiotic-resistant Escherichia coli (AR-E. coli) in the last stretch of two rivers (Arrone and Tiber) in Central Italy that differ in size and flow volume.