H2S metabolism in colon cancer cells exposed to hypoxia
Hydrogen sulfide (H2S), after nitric oxide (NO) and carbon monoxide (CO), is known as the third gasotransmitter. Involved in antioxidant protection and regulation of different physiological functions, H2S is synthesized by cystathionine β-synthase (CBS) and few other enzymes, and is oxidatively catabolized in the mitochondrion, where H2S-derived electrons are transferred to coenzyme Q by sulfide quinone oxidoreductase (SQR), stimulating respiration and ATP production. Metabolic and oncologic diseases are related to dysregulation of H2S metabolism.