Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2
Src Homology 2 (SH2) domains are a class of protein domains that present a conserved three-dimensional structure and possess a crucial role in mediating protein-protein interactions. Despite their importance and abundance in the proteome, knowledge about the folding properties of SH2 domain is limited.