Switchable length nanotubes from a self-assembling pH and thermosensitive linear L,D-peptide-polymer conjugate
Preparation and characterization of a pH and thermosensitive linear L,D-octapeptide-poly(dimethylamino ethyl methacrylate) ((L-Val-D-Val) 4 -PDMAEMA) conjugate is reported. The hydrophobic uncharged linear (L-Val-D-Val) 4 octapeptide was designed to self-assemble in nanotubes by exploiting the tubular self-assembling properties of linear peptides with regularly alternating enantiomeric sequences. pH and thermosensitive PDMAEMA was obtained by atom transfer radical polymerization (ATRP). The conjugate was prepared by click-chemistry on the solid phase synthetized peptide.