Gastrointestinal Malabsorption of Thyroxine
Levothyroxine, a largely prescribed drug with a narrow therapeutic index, is often a lifelong
treatment. The therapeutic efficacy of thyroxine may be marred by behavioral, pharmacologic
and pathologic issues acting as interfering factors. Despite a continuous search for an
optimal thyroxine treatment, a significant number of patients fail to show a complete
chemical and/or clinical response to this reference dose of thyroxine. Gastrointestinal
ADVANCE ARTICLE: Endocrine Reviews