Long term effects of mesoglycan on brachial arterial stiffness and MMP-9/TIMP-1 system in patients with metabolic syndrome
Objectives: The aim of this study was to evaluate the chronic effects of mesoglycan on the vascular
remodeling in patients with metabolic syndrome (Mets).
Background: MetS is defined by a clustering of vascular risk factors that require both pharmacologic
and non-pharmacologic interventions, including body weight reductions and physical activity. The
correction of vascular remodeling associated with MetS has lately received increasing interest.
Methods: Thirty consecutive ambulatory patients affected by MetS were 2:1 randomized in a doubleblind