Is oxidative stress involved in vernal keratoconjunctivitis? Results from a pilot study in children
Abstract
Background: Vernal keratoconjunctivitis (VKC) is a rare chronic conjunctivitis characterized
by a predominantly eosinophil-mediated inflammatory disorder that could
develop critical complications such as blindness. Oxidative stress plays a pivotal role
in the pathogenesis of several allergic diseases. The role of oxidative stress has been
hypothesized in VKC, but no study explored this issue. Furthermore, cyclosporine A
(CsA) exerts an anti-inflammatory and antioxidant action on the conjunctiva.