Free radical-mediated formation of trans-cardiolipin isomers, analytical approaches for lipidomics and consequences for the structural organization of membranes
Free radical-mediated processes, such as peroxidation, isomerization and hydrogenation affecting fatty acid integrity and biological functions have a trans-disciplinary relevance. Cardiolipins [CL, (1,3-diphosphatidyl-sn-glycerol)] and tetra-linoleoyl-CL are complex phospholipids, exclusively present in the Inner Mitochondrial Membrane (IMM) lipids where they maintain membrane integrity and regulate enzyme functionalities. Peroxidation pathways and fatty acid remodeling are known causes of mitochondrial disfunctions and pathologies, including cancer.