The Henry reaction, also named nitroaldolic, is one of the most important ways to form a C-C bond and it is promising due to its economy and high versatility of the nitro group,[1] which can be transformed in several functional groups through the Nef reaction.[2]
With the aim to easily recover and reuse the catalyst, an efficient amino alcohol catalyst previously tested in the asymmetric addition of diethylzinc to several aromatic aldehydes has been immobilized on proper functionalized superparamagnetic core−shell magnetite−silica nanoparticles and employed in the Henry reaction in the semi-homogeneous phase. The nanocatalyst exhibits a promising catalytic activity that remains unchanged in the three catalytic cycles performed.
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