Ricerc@Sapienza

We and others propose vimentin as a possible cellular target for the treatment of COVID-19. This innovative idea is so recent that it requires further attention and debate.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that is responsible
for coronavirus disease 2019 (COVID-19), which has rapidly spread across the world, becoming
a pandemic. The “cytokine storm” (CS) in COVID-19 leads to the worst stage of illness, and its timely
control through immunomodulators, corticosteroids, and cytokine antagonists may be the key to
reducing mortality. After reviewing published studies, we proposed a Cytokine Storm Score (CSs) to

Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by a non-cardiogenic pulmonary edema with bilateral chest X-ray opacities and hypoxemia refractory to oxygen therapy and low level of positive end-expiratory pressure (1).