CD3+CD4+LAP+Foxp3-regulatory cells of the colonic lamina propria limit disease extension in ulcerative colitis
Background and Aims: In ulcerative colitis (UC), inflammation begins in the rectum and
can extend proximally throughout the entire colon. The extension of inflammation is an
important determinant of disease course, and may be limited by the action of regulatory
T cells (Tregs). In this cross-sectional study, we evaluated the relationship between UC
extension and the proportions of CD3+CD4+Foxp3+ and CD3+CD4+LAP+Foxp3-
Tregs in the colonic lamina propria (LP) of 79 UC patients and 29 controls. The role of