Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer diseas
ObjectiveTo investigate whether baseline concentrations of plasma total tau (t-Tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD).MethodsThis was a large-scale study of 276 cognitively intact older adults from the monocentric INSIGHT-preAD (Investigation of Alzheimer's Predictors in Subjective Memory Complainers) cohort.