Ricerc@Sapienza

Background: In last years, many attempts were made to recognize chronic rhinosinusitis with nasal polyps (CRSwNP) phenotypes focusing on identifying relevant key pathogenic molecules. Polyps recurrence rate ranges from 4% to 60%, so it's clear that not all clinical and immunologic factors associated with recurrence are known.

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the substance responsible of the irritation caused by the contact of chili peppers with the skin or mucous membranes. This protoalkaloid acts by stimulating the transient receptor potential cation channel subfamily V member 1 (TRPV1), which is mainly expressed by nociceptive fibers of peripheral sensory neurons, but is also present in the central nervous system, and in some non-neuronal cells. Following the initial, intense neuronal excitation, a brief refractory period occurs.

Nasal polyposis (NP) is a chronic paranasal sinuses inflamma-tory disease causing severe nasal and systemic symptoms includingfatigue, sleeping problems, and impairments in social, emotionaland lifestyle conditions. Patients with severe eosinophilic asthma (SEA) have frequent comorbid NP, which may impact asthma severity.