Immunohistochemical detection of IL-17 and IL-23 improves the identification of patients with a possible diagnosis of Sjogren's syndrome
Objectives: The diagnosis of primary Sjogren’s syndrome (pSS) continues to be difficult and several patients keep
symptomatic for years with different diagnoses before confirmation of pSS. Since the IL-23-IL-17 axis is involved
in the etiopathogenesis of pSS we evaluated by immunohistochemistry and morphometric methods the presence
of IL-17 as well as IL-23 within minor salivary glands (MSG) obtained from patients with uncertain diagnosis of
pSS.
Materials and Methods: 42 patients, with symptoms attributable to pSS, and 8 patients used as a control, were